Probabilistic Genotyping DNA Analytical Software

The Vendor is required to provide a probabilistic genotyping software to process simple and complex DNA mixtures seen in casework.
- Must support efficient analysis of complex DNA mixtures, with a focus on accuracy, reproducibility, and handling of multiple contributors.
- Software capable of:
•    Handling a wide range of DNA mixtures, from simple to highly complex, and degraded samples;
•    Providing comprehensive statistical analysis, including likelihood ratios, and exclusion/inclusion data;
•    Performing developmental and internal validations;
•    Providing comprehensive onsite training for 14 unit personnel; and
•    The ability to work with multiple contributors in mixtures.
- Utilizing advanced instrumentation and data analysis software, analysts can interpret samples and establish scientific connections between individuals and criminal activities.
- The software must incorporate models for artifacts like stutter, allelic drop-in, dropout, amplification efficiency, and degradation to enhance interpretation accuracy.
- The software must support simultaneous processing of multiple DNA samples. 
- This capability is critical to improve laboratory efficiency and manage high workloads effectively, ensuring timely analysis and reporting.
- The system shall maintain accuracy and performance while processing multiple complex samples in parallel, minimizing turnaround times and preventing workflow bottlenecks.
- The software must provide efficient processing speeds to support the laboratory’s operational demands.
- Simple DNA mixtures should be processed within minutes to enable rapid casework turnaround. For more complex mixtures involving multiple contributors and challenging sample conditions, processing times should generally not exceed 6 hours. 
- These performance benchmarks ensure that the software balances thorough analysis with timely results, supporting effective case management without compromising accuracy or reliability.
- The system must incorporate relevant variables, including the number of contributors, peak heights, stutter, drop-in, dropout, and mixture proportions.
- The software should support the use of a unified statistic, treating alternate contributors as potentially related or unrelated individuals, to enhance interpretation accuracy.
- The software must generate comprehensive, clear, and well-structured reports that detail all critical aspects of the DNA mixture analysis. 
- Reports should include, but are not limited to, likelihood ratios, contributor exclusions and inclusions, and overall confidence measures for the analysis results. 
- These reports should be customizable to accommodate varying case requirements, different audiences such as laboratory staff, legal professionals, and courts, and formatting preferences.
- The resulting statistical output should be transparent, reproducible, and suitable for presentation in court.
- This includes the ability to model kinship scenarios, where a contributor may be a close relative of a person of interest, and to apply conservative population genetic assumptions to ensure the accuracy and reliability of the analysis.
- The software must include stand-alone licenses for individual workstations, with the ability to upgrade to concurrent licenses for multiple users, with flexibility in user count.
- The software needs to be compatible with Windows 11. If a web-based solution, the vendor must state if solution is also compatible with MS Edge or Chrome and if there are other client software requirements, or if any applicant components require plugins (e.g., JavaTM applets, ActiveX controls, etc.). The City’s preference is for a thin application that is browser agnostic.
- Notify the City immediately of any Information Security Incident;
- Investigate the Information Security Incident and conduct an analysis of the cause of the Information Security Incident;
- Develop and implement an appropriate plan to remediate the cause of such Information Security Incident;
- Provide periodic updates, including updates as requested by City, of any ongoing investigation to the City;
- Provide a copy of these certifications/audits, including the dates these were conducted.

- Contract Period/Term: 3 years
- Pre-Submittal Conference Date: October 23, 2025
- Questions/Inquires Deadline: October 27, 2025